The Russian rocket took off at the scheduled time from the Kazakh steppe.
The mission of American Frank Rubio from NASA and Russians Sergei Prokopiev and Dmitry Petelian from the space agency Roscosmos represents a rare example of cooperation between Moscow and Washington at a time when their relations are at their lowest ebb.
Rubio is the first American astronaut to go to the ISS on a Russian rocket since the start of the Russian aggression against Ukraine on February 24.
The crew is to spend six months on the International Space Station, where there are three Russian and three American cosmonauts, as well as an Italian woman.
This is the first flight for Franco Rubio and Dmitry Petelin and the second for Sergei Prokopiev.
Docking with the Russian segment of the MSS is scheduled after the Soyuz rocket’s three-hour journey.